The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could cause an increase in methadone plasma concentrations, which could lead to most likely deadly respiratory melancholy. Moreover, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also bring about a rise in … Read More